Writing The Wrongs: Israel's CorAssist keeps a weak heart pumping

Monday, October 27, 2008

Israel's CorAssist keeps a weak heart pumping

Karin Kloosterman October 27, 2008

Heart attacks grab headlines, they take lives. A little known fact is that millions of Americans are at risk of heart disease, with a full-blown heart attack being only one of the unfortunate consequences that can lead to death. With decades of experience taking cardiac-related biotech companies to market, in 2006 Amir Loshakove joined CorAssist. As its general manager, Loshakove is working once again with hearts. "The most exciting thing in the world is to treat hearts," he tells ISRAEL21c.

In the process of raising $15 million, CorAssist has already started human clinical trials using a small device that restores power to weakened heart muscles. According to Loshakove, there are two major conditions related to heart failure, namely, systolic and diastolic heart failure.

First to market

While some devices to treat systolic heart failure (SHF) are already in clinical trials, no devices to treat diastolic heart failure (DHF) are available. CorAssist's solution presents the first device-based approach to treat DHF, being a one-of-its-kind product in the market.

After a heart attack, or with heart muscle disease due to obesity and other conditions such as genetic defects, the heart muscles have a difficult time squeezing blood to the body (the systolic phase), and then back again into the heart (the diastolic phase). CorAssist is focusing on the second condition - DHF - where a person's heart inadequately relaxes, and is impaired in its capability to return blood from the body back to the heart.

According to the New York Heart Association, over five million people in the US suffer from heart failure. About half of these people suffer from diastolic heart failure, for which there is no effective treatment. Affecting mainly women, the overweight, smokers, and people with diabetes and other predisposing diseases and conditions, DHF results in the stiffening of the heart muscles.

Don't still my beating heart

CorAssist's main product is the ImCardia, which works from outside the heart. It's a self-expanding device that attaches to the external surface of the left ventricle. When the heart muscle squeezes, energy is loaded into the device, which absorbs this energy, and releases it to the left ventricle in the diastolic phase. This keeps the muscles elastic, giving it a small "work out" to improve heart health.

So far, safety studies on three people - in South America and Eastern Europe - have found the ImCardia safe for implantation. Next year, the company is gearing up for a larger trial. And it could take as little as two years for the company to get FDA approval, allowing the much-needed solution to be available in the US.

CorAssist is a 14-person company based in Herzylia, Israel. Founded in 2003 by three Israeli physicians - Yair Feld, Yotam Reisner and Shay Dubi - it keeps a number of world-renowned heart specialists and scientists on its advisory team, and includes Prof. William Little, from Wake Forest University School of Medicine, North Carolina; Prof. Michael Zile from the Medical University of South Carolina, and Prof. Mitchell Krucoff from Duke University Medical Center.

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U.S. scholars' group votes in favor of academic boycott of Israel

US-Israeli talks focus on Ahmadinejad's possible ouster

Why reconstruct Gaza without making demands

Ted Belman

The US and EU are putting up $2.3 Billion to redevelop Gaza.

Before advancing any money, why don’t they insist

- that Shalit be release without convicted terrorists being released by Israel in exchange,

- that the US be put in charge of the southern border to ensure that Hamas isn’t rearmed?

- that their three preconditions be accepted by Hamas, i.e. agree to all former agreements,recognize Israel and renounce terror

- that Hamas amend their Charter

- That Hamas disconnect from Iran

The answer is that they don’t want to.

IDF: Civilian Deaths in Gaza Less than 25% of Total

A maximum of 25% of the Palestinians killed in Gaza since the beginning of the Israeli operation are innocent civilians, the head of the IDF's Gaza Coordination and Liaison Administration (CLA), Col. Moshe Levi, said Wednesday. According to Palestinian medical officials, Israel has killed some 1,000 Palestinians and more than half of them are civilians. Levi said the CLA had compiled a list with the names of 900 Palestinians killed during the fighting. He said that 150 names were of women, children and elderly, and that the maximum number of civilians killed so far was 250.
Levi also dismissed claims that 43 Palestinians were killed in an IDF attack on a Hamas terror cell that was firing mortars at Israeli forces from within an UNRWA school in Jabalya. Levi said 21 Palestinians were killed in the attack, including a number of Hamas operatives. (Jerusalem Post)

Iranian reformist daily:Hamas hiding forces in nurseries and hospitals

An Iranian reformist daily newspaper has criticized Hamas "for risking lives of civilians, amongst them children, by hiding its forces in nurseries and hospitals." This is reported in today's Palestinian daily Al-Ayyam. The Palestinian daily adds that in response the Iranian government has closed the newspaper.

The following is the story in today's Al-Ayyam:

Headline: "Iran closes a reformist newspaper, for publishing a report criticizing Hamas"

"The Iranian news agency "Irna" reported yesterday, that the Iranian Culture Ministry has closed the reformist daily newspaper "Karjo Zaran", because it published a report that included criticism of the Islamic Resistance Movement (Hamas).
On December 30 the paper published a statement of a reformist student organization, that has criticized Hamas for risking lives of civilians, amongst them children, by hiding its forces in nurseries and hospitals. The statement was published whilst the Iranian government expresses a unified stands against Israel, and Tehran is overwhelmed by demonstrations against Israel."

[Al-Ayyam, Jan. 1, 2009]
Thanks PMW

Iran-backed Hamas Rocket, Mortar Attacks and Nuclear Developments

9,400+ rockets and mortars fired from Gaza since 2003. [1]
3,200+ rockets and mortars fired from Gaza in 2008 alone. [2]
6,500+ rockets and mortars fired from Gaza since Israel withdrew from Gaza in 2005. [3]
543+ rockets and mortars fired from Gaza into Israeli territory during the ceasefire from June 19 to Dec. 19, 2008. [4]
28 deaths caused by rockets and mortars fired from Gaza into Israel since 2001. The dead include Israelis, Palestinians and foreign workers. Since the ceasefire ended, Iran-backed Palestinian groups in Gaza fired rockets and mortars that killed an Israeli-Arab construction worker and a mother of four who was seeking shelter in a bus station as a rocket warning siren sounded. [5]
1,000+ people in Israel injured from rockets and mortars fired from Gaza since 2001, including Israelis, Palestinians and foreign workers. Since the ceasefire, 44 Israelis have been injured and 200 have been treated for shock. [6]
Thanks Israel Project

It began with this...

The British Foreign Office, November 2nd, 1917
Dear Lord Rothschild,
I have much pleasure in conveying to you, on behalf of His Majesty’s Government, the following declaration of sympathy with Jewish Zionist aspirations which has been submitted to, and approved by, the Cabinet.

“His Majesty’s Government view with favour the establishment in Palestine of a national home for the Jewish people, and will use their best endeavours to facilitate the
achievement of this object, it being clearly understood that nothing shall be done which may prejudice the civil and religious rights of existing non-Jewish communities in
Palestine, or the rights and political status enjoyed by Jews in any other country.”
I should be grateful if you would bring this declaration to the knowledge of the Zionist Federation.2

Signed,
Arthur James Balfour
[Secretary of State for Foreign Affairs]

Syria is an Occupier-Are You Listening World?

Syria Occupies Lebanon. Again. - Bret Stephens (Wall Street Journal)

As of this minute, Syria occupies at least 177 square miles of Lebanese soil. That you are now reading about it for the first time is as much a scandal as the occupation itself.

The news comes by way of a fact-finding survey of the Lebanese-Syrian border just produced by the International Lebanese Committee for UN Security Council Resolution 1559, an American NGO that has consultative status with the UN. In meticulous detail - supplemented by photographs and satellite images - the authors describe precisely where and how Lebanon has been infiltrated.

Though the land grabs are small affairs individually, they collectively add up to an area amounting to about 4% of Lebanese soil - in U.S. terms, the proportional equivalent of Arizona. Of particular note is that the area of Syrian conquest dwarves that of the Israeli-occupied Shebaa Farms which amount to an area of about 12 square miles.

It would be nice to see the Arab world protest this case of illegal occupation, given its passions about the subject.